background and objectives: giant cell tumor of bone (gct) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. histological features of the tumor often could not predict its future biologic behavior, so it is just called ''giant cell tumor'' without indicating malignancy or benig...

background and objectives: apoptosis of eosinophils is of significant value in assessing the airway inflammation in patients with asthma. our purpose was to investigate the degree of expression of the bcl-2 protein in sputum eosinophils during acute asthma exacerbation and its relationship with exacerbation severity.    materials and methods: the study was carried out in mostafa khomeini hospit...

Background: Secretory proteins of IgE receptor activated mast cells and basophils play a pivotal role in the generation of immediate and long term immune responses in allergy and type I hypersensitivity. Objective: The present study aims to generate a 2-D map and profile of proteins secreted from a high secretory variant of the rat basophilic leukemia cell line, RBL-2H3.1, which in view of the ...

Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes.Due to changes in the expression of these proteins...

background: candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. it is speculated that structural and secretory proteins of c. albicans have immunomodulatory effects in cancer. objective: to evaluate the effects of c. albicans structural and secreted proteins on intratumoral cd4/cd8 ratio as well as the survival rate in balb/c t...